Professor
Education
Ashland College, 1971, B.S.
University of South Carolina, 1976, Ph.D.
Harvard Medical School, 1979, Postdoctoral
Research Interests
Elucidation of the cellular response to environmental and toxic insult. Regulation of human metallothionein and stress response gene expression. Isolation and characterization of differentially-expressed genes in disease states. Formation of model systems based on the use of human tissue.
Recent Publications
Haber DA, Park S, Maheswaran S, Englert C, Re GG, Hazen-Martin DJ, Sens DA, Garvin AJ: WT1 suppresses growth of a Wilms' tumor cell line expressing an alternatively spliced endogenous transcript. Science 262:2057-2059, 1993.
Inactivation of WT1 in nephrogenic rests, genetic precursors of Wilms' tumor. Nature Genetics 5:363-367, 1993
Mididoddi S, McGuirt JP, Sens MA, Todd JH, Sens DA: Isoform-Specific Expression of Metallothionein mRNA in the Developing and Adult Human Kidney. Toxicol. Lett. 85:17-27, 1996.
Expression of heat shock protein 27 in developing and adult human kidney. Toxicol. Lett. 84:69-79, 1996.Expression of heat shock protein 27 in adult human third molar dental pulp. J. Oral Pathol. Med. 25:382-387, 1996.
Sens DA, McGuirt JP, Khan W, Howell RM, Todd, JH: Expression of Hsc 70, but not Hsp 70, in human third molar dental pulp. Eur. J. Oral Sci. In Press.
Hoey JG, Garrett SH, Sens MA, Todd JH, Sens DA: Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma. Toxicol. Lett. In Press.
Friedline JA, Garrett SH, Todd JH, Somji S, Sens DA: Differential expression of the MT-1E gene in estrogen receptor positive and negative human breast cancer cell lines. Am. J. Pathol., Under Review, 1997.