Curriculum Vitae
August, 1997
Nyles W. Charon

PERSONAL DATA, EDUCATION, PROFESSIONAL POSITIONS

Personal Data
Born: September 13, 1943
Citizenship: U.S.

Education and professional positions
University of Minnesota 1961-65 BA in Microbiology, 1965
University of Minnesota
 Advisor: R.C. Johnson
1965-69 MS in Microbiology, 1969
University of Minnesota
 Advisor: R.C. Johnson
1969-72 Ph.D. in Microbiology, 1972
Stanford University
 Advisor: A.M. Campbell
1972-74 Postdoctoral, Biological Sciences
West Virginia University 1974- Department of Microbiology and Immunology
   Assistant Professor
   Associate Professor
   Professor
1974-80
1980-87
1987-
University of Pittsburgh
 Advisor: Dr. R. Hendrix
1991-92 Sabbatical

PROFESSIONAL ACTIVITIES

Professional Organizations
  American Leptospirosis Conference
  American Society for Microbiology
  American Association for the Advancement of Science

Peer Review
 Grants: NIH Study Panel in Centers in Oral Biology, Periodontology. Ad hoc reviewer for NIH Study Panels: Bacteriology and Mycology, Oral Biology and Medicine, Small Business Grants. Ad hoc reviewer for NSF, USDA, Veterans Administration, North Carolina Biotechnology Center, and other regional funding agencies.

 Journals: Editorial Board of Journal of Bacteriology, 1993-1998; Ad hoc reviewer for Infection and Immunity, American Journal of Public Health, International Journal of Systematic Bacteriology, Microbiological Reviews, Molecular Microbiology, Microbiology, Gene.

 Honors:
MacLachlan Award, Outstanding Teacher Award, School of Medicine, 1981-1982.
Invited Speaker: Annual Meeting American Society for Microbiology. 1990, 1991, 1994;
  Japanese Society for Microbiology., 1994.
  International Spirochete Meetings: 1984, U.S.; 1989, England; 1991, France
  Bacterial Locomotion and Sensory Transduction. 1991, 1997.
President, American Leptospirosis Research Conference, 1985-86.
Chair, Gordon Conference, Biology of the Spirochetes, 1994; Speaker, 1996.

Recent Publications
Limberger, R.J., L.L. Slivienski, D.B. Yelton, and N.W. Charon. 1992. Molecular genetic analysis of a Class B periplasmic flagellum gene of Treponema phagedenis. J. Bacteriol. 174:6404-6410.

Goldstein, S.F., N.W. Charon, and J.A. Kreiling. 1994. Borrelia burgdorferi swims with a planar waveform similar to eukarytoic flagella. Proc. Natl. Acad. Sci. U.S.A. 91:3433-3427.

Ge, Y., I. Old, I Saint Girons, D.B. Yelton, and N.W. Charon. 1996. FliH and FliI of Borrelia burgdorferi are similar to flagellar and virulence factor export proteins of other bacteria. Gene 68:73-75.

Li.H. J. Ruby, N. Charon, and H. Kuramitsu. 1996. Gene inactivation in the oral spirochete Treponema denticola: construction of a flgE mutant. J. Bacteriol. 178:3664-3667.

Goldstein, S.F., K.F. Buttle, and N. W. Charon. 1996. Structural analysis of the Leptospiraceae and Borrelia burgdorferi using high voltage electron microscopy. J. Bacteriol. 178:5539-6545.

Ge, Y., and N.W. Charon. 1997. An unexpected flaA homolog is present and expressed in Borrelia burgdorferi. J. Bacteriol.179:552-556.

Ruby, J.D. H. Li, H. Kuramitsu, S.J. Norris, S. F. Goldstein, K. Buttle, and N. W. Charon. 1997. Relationship of Treponema denticola periplasmic flagella to irregular cell morphology. J. Bacteriol. 179. 1628-1635.

Ge, Y., and N. W. Charon. 1997. Identification of a large motility operon in Borrelia burgdorferi by semi- random PCR chromosome walking. Gene 189:195-201.

Ge, Y., I. Old, I. Saint Girons, and N.W. Charon. 1997.The flgK motility operon of Borrelia burgdorferi is initiated by a s70-like promoter. Microbiology. 143: 1681-1690.

Ge, Y. I. G. Old, I. Saint Girons, and N. W. Charon. 1997. Molecular characterization of a large Borrelia burgdorferi motility operon which is initiated by a consensus s70 promoter. J. Bacteriol. 179:2289-2299.

Ge, Y. and N. W. Charon. 1997. FlaA, a putative flagellar outer sheath protein, is not an immunodominant antigen associated with Lyme disease. Infect. Immun. 65:2992-2995.

Ge, Y. and N. W. Charon. 1997. Molecular characterization of a flagellar/chemotaxis operon in the spirochete Borrelia burgdorferi. FEMS Letters. In press.