William E. Wallace

Education:

B.S., M.S., Ph.D. (Physics): West Virginia University, 1963, 1967, 1969

Teaching

Ch.E.280:ChemicalProcess Safety:Occupational Safety & Health in Chemical Engineering

Research Advisor

National Research Council - NIOSH Postdoctoral Research Associateship Program

Research Interests

Spectroscopic analyses of respirable particle surface properties and of pulmonary surfactant interactions with respirable particles affecting the expression of cytotoxicity or genotoxicity.

Selected Publications or Reports

International Agency for Research on Cancer (IARC) Monograph Programme on the Evaluation of the Carcinogenic Risk of Chemicals to Humans - Volume 34: "Industrial Processes Involving Exposures to Polycyclic Organic Compounds"; World Health Organization (1984).

Wallace WE, Vallyathan V, Keane MJ, Robinson V, "In Vitro Biological Toxicity of Native and Surface Modified Silica and Kaolin". Journal of Toxicology and Environmental Health, 16, 415424 (1985).

Wallace WE, Keane MJ, Hill CA, Xu J. Ong TM, "Mutagenicity of Diesel Exhaust Particles and Oil Shale Particles Dispersed In Lecithin Surfactant". Journal of Toxicology and Environmental Health, 21 165 (1987).

Wallace WE, Keane M, Xing S. Harrison J. Gautam M, Ong T. "Mutagenicity of Diesel Exhaust Soot Dispersed in Phospholipid Surfactants" . in "Environmental Hygiene II", pp. 7-10; Eds.NH Seemayer and W Hadnagy, Springer Verlag, Berlin, ISBN 0-387-52735-4 (1990).

Wallace WE, Harrison J. Keane MJ, Bolsaitis P. Epplesheimer D, PostonJ. Page Page SJ, "Clay Occlusion of Respirable Quartz Particles Detected by Low Voltage Scanning Electron Microscopy - X- Ray Analysis", Annals of Occupational Hygiene 34 195-204 (1990).

Keane MJ, Xing SO, Harrison J. Ong TM, Wallace WE, "Genotoxicity of Diesel Exhaust Particles Dispersed in Simulated Pulmonary Surfactant". Mutation Research 206 233-238 (1991).

Gu ZW, Zhong BZ, Nath B. Whong WZ, Wallace W. Ong T. "Micronucleus Induction and Phagocytosis in Mammalian Cells Treated with Diesel Emission Particles". Mutation Research. 279: 55-60 (1992).

Wallace WE, Keane MJ, Mike PS, Hill CA, Vallyathan V, Regad ED. "Contrasting Respirable Quartz and Kaolin Retention of Lecithin Surfactant and Expression of Membranolytic Activity Following Phospholipase A2 Digestion." J Tox. and Env. Hlth.37: 391-409 (1992).

William E. Wallace and Michael J. Keane. "Differential Surface Composition Analysis by Multiple- Voltage Electron Beam X-Ray Spectroscopy." United States Patent # 5,210,414; May 11, 1993.

Lu L, Keane MJ, Ong T. Wallace WE, "In Vitro Genotoxicity Studies of Chrysotile Asbestos Fibers Dispersed in Simulated Pulmonary Surfactant". Mutation Research 320 253-259 (1994).

Gu ZW, Zhong BZ, Keane MJ, Whong WZ, Wallace WE, Ong TM, "Induction of

Unscheduled DNA Synthesis in V79 Cells by Diesel Emission Particles Dispersed in Simulated Pulmonary Surfactant". Annals of Occupational Hygiene 38 Supplement 1, 345-349 (1994).

Wallace WE, Harrison J. Grayson RL, Keane MJ, "Aluminosilicate Surface Contamination of Respirable Quartz Particles from Coal Mine Dusts and from Clay Works Dusts" Annals of Occupational Hygiene 38 Supplement 1, 439-445 (1994).

Hill CA, Wallace WE, Keane MJ, Mike PS. "The enzymatic removal of a Surfactant coating from quartz and kaolin by P388D1 cells". Cell Biology and Toxicology 11: 119-128 (1995).

Wallace WE, Keane MJ, Harrison JC, Stephens JW, Brower PS, Grayson RL, Attfield MD. "Surface properties of silica in mixed dusts". In: "Silica and silica-induced lung diseases", pp.107-117; Ads. V Castranova, V Vallyathan, WE Wallace, CRC Press. (1995).

Liu X, Keane MJ, Zhong BZ, Ong T. Wallace WE. "Micronucleus formation in V79 cells treated with respirable silica dispersed in medium and in simulated pulmonary surfactant". Mutation Research 361: 89- 94 (1996).

Harrison J. Brower P. Attfield MD, Doak CB, Keane MJ, Wallace WE. "Surface composition of respirable silica particles in a set of US anthracite and bituminous coal mine dusts". Journal of Aerosol Science. 28: 689-696 (1997).