Project Number: WVA00393
CRIS Number: 0175270
PREVENTION OF ADVANCED GLYCOSYLATION ENDPRODUCT-INDUCED TISSUE COMPLICATIONS, BROILER-BREEDER CHICKEN
Investigators: Klandorf, H.
Performing Department: Animal & Veterinary Science -- 1877
Start Date: 10/01/1997
Termination Date: 09/30/2002
Reporting period: 01/01/2001 to 12/31/2001
Progress Report:
Studies were designed to compare the concentrations of plasma purine derivatives in broilers and turkeys fed inosine-supplemented diets and to show that allantoin, an oxidation product generated from uric acid, is present in birds. The first study consisted of 18 male broilers that were fed diets supplemented with 0.6 mol inosine or hypoxanthine from 3-wk-old to 5-wk-old. Study 2 consisted of 12 medium white toms that were fed inosine-supplemented diets (0.7 mol/kg) from 6-wk-old to 8-wk-old. Plasma purine derivative concentrations were measured weekly using HPLC. Broilers fed inosine-supplemented diets had higher plasma uric acid than turkeys (P
Publications:
Klandorf, H., Rathore, D.S., Iqbal, M., Shi, X., Van Thiel, D.H. and Van Dyke, K. 2001. Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. Comp. Biochem. Physiol. 129, 93-104.
Klandorf, H., Rathore, D.S., Iqbal, M., Shi, X. and Van Dyke, K. 2001. Acceleration of tissue aging in chickens caused by oxidative stress and detected by humoral chemiluminescence. pp. 393-407. In: Luminescence Biotechnology: Instruments and Applications. Ed. K. Van Kyke. CRC Press.
Simoyi, M.F., Van Dyke, K., and Klandorf, H. 2001. Manipulation of plasma uric concentration in broiler chicks and its effect on luminol-based chemiluminescence dependent oxidative stress. The FASEB Journal.
Impact:
Uric acid may have an important role in poultry health and in the prevention of disease.